This publication is a practical resource for decision-makers, organizations and individuals working in the field of drug policy who want to strengthen their strategies or promote new areas of collaboration by incorporating the basic components of the social innovation approach. This guide gathers the key elements and lessons learned generated in the process of design, implementation and evaluation of the 5 social innovation laboratories in the Latin American and Caribbean region within the framework of the COPOLAD III program and in collaboration with the Agirre Center.